A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin ...

Its speech measures reflected clinical scores and HD-related changes over time, suggesting it could be used as a remote ...

Most of us know what it’s like to have something stuck in our minds. A catchy song. A favourite YouTube video you watch again. A conversation that keeps circling in your mind. Usually, our brains move ...

Two of the biggest buckets of research into HD therapeuticstherapeutics treatments today are huntingtin-lowering and somatic instabilitysomatic expansion A process in which the CAG repeat in the ...

Day 3 of #HD2026 put HTT under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT ...

Day 2 of #HD2026 brought us updates on the mechanics of somatic instability, new ways to track HD in people, AI tools to help drive research forward, and developments in our understanding of the HTT ...

Day 1 of HD2026 is a wrap! From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to ...

Roche’s announcement that they were ending two of their HD programs was genuinely disappointing, and it leaves behind some unanswered questions. Was huntingtin lowered enough in the brain regions that ...

Scientists screened over a trillion tiny ring-shaped protein fragments to find ones that can grab onto the huntingtin. They captured huntingtin straight out of cells and discovered it’s almost always ...

Today, Roche announced in a community letter difficult news for the Huntington’s disease (HD) community, discontinuing two separate clinical programmes after new data emerged from ongoing studies. The ...

For the past 20 years, PET tracers have been a game-changer for Alzheimer’s disease, making it possible to see amyloid plaques in the brain without invasive procedures. So what about Huntington’s? The ...

uniQure shared in a press release on June 17, 2026 that the Food and Drug AdministrationFood and Drug Administration The government regulatory authority in the US responsible for approving new drugs ...