Learn more about eLife assessments The distribution of synaptic and extra-synaptic AMPA receptors (AMPARs) on neuronal plasma membranes is correlated with learning and memory. Although AMPAR ...

This valuable study substantially improves the phylogenetic framework for Kinetoplastea through greatly expanded sampling of free-living neobodonids; the phylogenomic analyses provide convincing ...

eLife reviews research in areas including cell migration, proliferation and differentiation, and inductive and signaling interactions. Learn more about what we review and sign up for the latest ...

eLife reviews plant biology research including development, epigenetics, genomics, signalling, metabolism and plant-microbe interactions. Learn more about what we review and sign up for the latest ...

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

Analysis of knockout and knockdown melanoma cells and TCGA melanoma data shows that the microphthalmia-associated transcription factor (MITF) is a major repressor of extracellular matrix (ECM) and ...

eLife has changed its editorial process to eliminate accept/reject decisions after peer review and instead provide readers with richer and more nuanced assessments of articles. eLife changed its ...

Red blood cells (RBC) must coordinate their rate of growth and proliferation with the availability of nutrients, such as iron, but the signaling mechanisms that link the nutritional state to RBC ...

This is a valuable contribution to our understanding of how some bacteria can transport sterols from the cytoplasm to the outer membrane. Though much remains to be tested and explored, the data and ...

Signalling pathways leading to post-synaptic plasticity have been examined in many types of experimental studies, but a unified picture on how multiple biochemical pathways collectively shape ...

This study presents valuable findings on the changes in immune cell populations and stromal cells occurring at the CNS borders in a neonatal bacterial meningitis model, focusing on fibroblasts, ...

Animal genomes are organized into topologically associated domains (TADs). TADs are thought to contribute to gene regulation by facilitating enhancer-promoter (E-P) contacts within a TAD and ...