Neurotransmitter receptors and ligands play a fundamental role in chemical signaling throughout the nervous system by controlling how messages are received and processed by neurons. Direct signaling ...

ABSTRACT: This paper adopts the philosophical theory of mental monism and examines the constraints on models of embodiment within that framework. It proposes a biologically plausible model of ...

Brief description: ELFN1 interacts with the apical surface of mGlu7 and acts as a positive allosteric modulator by triggering a conformational change of the receptor. This enabled development of an ...

Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1 (ELFN1) is a synaptic adhesion protein, which regulates the precise positioning and physiological functions of ...

To transmit excitatory signals, nerve cells mostly use glutamate as a neurotransmitter. To detect these transmitter signals, the cells can rely on a whole repertoire of receptors with different ...

In a groundbreaking study poised to shift paradigms in neurodegenerative disease research, Lu, Zhang, Chen, and colleagues have unveiled a novel mechanism by which metabotropic signaling downstream of ...

The nicotinic acetylcholine receptors (nAChRs) are key modulators of synaptic transmission and cognitive processing within the central nervous system. These ligand-gated channels, composed of various ...

Daphnia, commonly known as water fleas, are tiny crustaceans that live in freshwater ponds and lakes. When they sense predators in their surroundings, these small organisms can swiftly move away or ...

Geneva, Switzerland, April 21, 2026-Addex Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric ...

Glucagon-like peptide-1 (GLP-1) receptor agonists are incretin analogues that promote glucose-mediated insulin release and are used to treat type 2 diabetes mellitus and obesity. GLP-1 receptor ...

Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a chronic condition with severe pelvic pain and urinary symptoms significantly impairing quality of life. This study investigated the clinical ...

The metabotropic glutamate receptor 6 (mGlu6) is essential for synaptic communication of rod photoreceptors, and mutations in mGlu6 lead to a blinding disorder. However, its structural organization ...