* The TOWARD program provides coaching and support to help participants to follow a ketogenic diet (carb intake of 30g/day or lower).

* This is the first of a two-part note reviewing the classic Ference et al consensus statement on LDL and ASCVD, which was published in 2017. * The publication claimed that low density lipoproteins ...

* Last week we reviewed the April 2026 Cochrane report, which evaluated a class of drugs (amyloid-beta-targeting monoclonal antibodies) for the treatment of Alzheimer’s disease (AD). * The report ...

Many thanks for all your comments about this series. Hopefully it was thorough enough that I can put it to bed for some time. I’ve been asked for an executive summary, so here it is. Next week we have ...

We’re on the second of a four part note documenting “How to read a paper.” Last week we looked at the levels of evidence. That’s the starting point to understand what we are reading and how robust it ...

This is the final of three articles looking at the statin trials that have been conducted and the pooling together of those trials with the technique called meta-analysis. The Clinical Trial Service ...

This note is the first of three, on a topic that I have wanted to comprehensively cover for some time. Dr Malcolm Kendrick and I did a lot of work on all the statin trials for the defamation case that ...

* This week's note looks at a classic statin/heart-disease study from 1994 – the Scandinavian Simvastatin Survival Study (abbreviated to 4S). * Simvastatin was made by Merck & Co. Merck funded, ...

* This is the third of three notes looking at the October 2025 Planetary Health Diet (PHD) publication (Ref 1). The first note reviewed the many nutritional deficiencies in the recommended diet. The ...

* This note examines two research questions with original references of the time: i) How was any connection between cholesterol and heart disease first made? ii) Does eating cholesterol raise blood ...

* The results of a diet clinical trial have just been published by authors from University College London and University College London Hospital (UCLH). * The trial aimed to compare two diets both ...