The Bacille Calmette-Guérin vaccine, formulated more than a century ago to protect people from tuberculosis, is also in use to prevent relapse in people who have had surgery for bladder cancer. If ...

Synapses in the hippocampus dwindle with age. Might a little-known, lipid-cleaving enzyme keep them from withering away? In the October 15 Nature Neuroscience, scientists led by Amar Sahay at Harvard ...

Digging deeper into the genetic causes of Alzheimer’s disease, some scientists are studying epigenetic regulation. In the October 12 Nature Aging, a group led by Jinying Zhao at the University of ...

How much do blood-based biomarkers help in diagnosing Alzheimer’s disease? Quite a lot, according to scientists led by Albert Puig Pijoan and Marc Suárez-Calvet at the Hospital del Mar in Barcelona, ...

When it comes to new brain anatomy, clearance pathways seem to be the gift that keeps on giving. In a preprint posted September 27 on bioRxiv, scientists led by David Attwell at University College ...

In the latest development on diagnostic methods for Alzheimer’s disease going mainstream, the U.S. Food and Drug Administration approved clinical use of Lantheus’ tau PET tracer florquinitau, aka ...

The tau locus comes in two major genetic configurations, the H1 and H2 haplotypes. The latter carries a stretch of DNA, including the tau gene, that is flipped in orientation. As it turns out, a ...

Ask a clinician or a researcher about the blood-brain barrier (BBB) in Alzheimer’s disease, and you may hear about amyloid or leaky tight junctions. Fibronectin, a major scaffold protein, won’t ...

Can brain amyloid reduction be used as a surrogate biomarker of clinical benefit? This is a hotly debated question in the field (see Dec 2024 discussion). A recent post hoc analysis of Phase 3 ...

CAR-T cell therapy has practically become a household name, given its success in taking down blood cancers. The chimeric antigen receptors used in this type of cell therapy are designed to sic killer ...

White-matter hyperintensities, a sign of damage to the brain’s vasculature, are common on MRI scans of people with Alzheimer’s disease. Do they indicate an independent vascular co-pathology, or are ...

In the setting of Alzheimer’s and other neurodegenerative diseases, do T cells make things better, or worse? A simple answer just won’t do—it likely depends on the type of T cells, where they are in ...