Target ALS is proud to announce that three consortia have been selected for awards through our Biomarker Consortia Program. As new therapeutics begin moving the needle for people with ALS, the field ...
Antisense Oligonucleotide Tofersen Distribution in the Central Nervous System of SOD1-ALS Autopsy Tissue Donors. Guise AJ, Sellon MT, Roemer SF, Monine M, Comfort Harris NT, […] Plowey ED. JAMA Neurol ...
The Target ALS Postmortem Core has now collected brain and spinal cord tissue from over 650 cases, making it the largest and most comprehensive ALS tissue repository worldwide that is accessible with ...
The Target ALS Global Natural History Study (GNHS) is entering a new phase of discovery. As the only international, longitudinal study generating deeply characterized clinical, genomic, and biofluid ...
ALS is a heterogeneous disease with distinct subpopulations of cases clustering together based on common underlying biology and with distinct differences in the clinical time course and manifestation ...
People carrying mutations known to cause ALS make up at least 10% of the ALS cases. These mutations are often not fully penetrant, leaving these individuals with uncertainty as to whether they will ...
Artificial intelligence and machine learning now enable the rapid virtual design and testing of thousands of new molecules and the simulation of their interactions with therapeutic targets. Leading ...
Today, we mourn the loss of Brooke Eby. Brooke was a powerhouse. Witty, clever, joyful, and direct. She was unwilling to be silenced by ALS. To take a fatal diagnosis at 33 and find humor in it, and ...
Key information that you need to know about planning for life with ALS. When you’re diagnosed with ALS, there are some decisions that can be helpful to understand early. Most decisions can wait until ...
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In observational studies, researchers collect data from study participants without intervening in their care. Clinical trials evaluate the safety and efficacy of a specific intervention, like a drug, ...
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