The metabotropic glutamate receptor 6 (mGlu6) is essential for synaptic communication of rod photoreceptors, and mutations in mGlu6 lead to a blinding disorder. However, its structural organization ...

Depression remains a leading cause of global disability, with current therapies often requiring weeks to achieve efficacy and failing in a significant subset of patients. Modulation of metabotropic ...

Brief description: ELFN1 interacts with the apical surface of mGlu7 and acts as a positive allosteric modulator by triggering a conformational change of the receptor. This enabled development of an ...

Neurotransmitter receptors and ligands play a fundamental role in chemical signaling throughout the nervous system by controlling how messages are received and processed by neurons. Direct signaling ...