The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been ...

Foxglove plants, found in many gardens, are known for the showers of bell-shaped flowers they produce. But plants belonging to this genus, Digitalis, also harbor a less visible asset: chemicals called ...

Foxglove plants are known to be shaped like bells and have long decorated many gardens. They belong to a genus of plants, Digitalis, and have been studied for a particular asset they hold—a chemical ...

Foxglove plants, found in many gardens, are known for the showers of bell-shaped flowers they produce. But plants belonging to this genus, Digitalis, also harbor a less visible asset: Chemicals called ...

Digitalis has been used to treat heart failure for more than 200 years. The drug digitoxin also belongs to this group of active ingredients known as cardiac glycosides. Although there were indications ...

Plant-derived glycosides, notably the cardenolide and bufadienolide families exemplified by digoxin, digitoxin and oleandrin, are potent modulators of cardiac function. These compounds exert effects ...

Cardiac glycosides derived from the foxglove plant have been used in cardiology for two centuries, but digoxin and digitoxin have gradually fallen out of favor and are now considered controversial in ...

Effect of extrahepatic disease on transarterial chemoembolization for metastatic carcinoid. Background: Wild toad venom has been used for over 1,000 years as a traditional Chinese medicine; H, the ...

Non-antibiotic drugs can alter the microbiome and increase the risk of gut infections in surprising ways, a new Nature study shows. A 240-year-old drug called digoxin could save the National Health ...

BILCAP: A randomized clinical trial evaluating adjuvant chemotherapy with capecitabine compared to expectant treatment alone following curative surgery for biliary tract cancer. Inactivation of BRCA2 ...