Deep inside the brain, a tiny antenna on each neuron may determine how gracefully the body ages. A new study reports that ...

From autophagy and seasonal health practices to barley germination, meditation and the symbolism of nine, Navratri offers an ...

A review identifies lysosomal pH dysregulation as a plausible context-dependent amplifier of sepsis-associated lung injury, but finds that most supporting mechanisms remain extrapolative or ...

Revealed by Latest Science] Muscles are not "broken to be made bigger." The truth and optimal solution for muscle hypertrophy ...

The FDA -aligned pivotal efficacy population includes 12 male patients receiving commercial-grade RP-A501 at the recalibrated dose. The first three patients treated under the modified protocol count ...

In a landmark biomedical breakthrough that challenges decades of conventional cell biology, an international team of researchers has demonstrated that autophagy—the body's internal cellular ...

Noboru Mizushima is a cell biologist who has studied the molecular mechanisms and in vivo roles of autophagy, a process by which cells degrade their own cytoplasmic components. He is currently a ...

Lysosomal dysfunction and neurodegeneration are two processes that often go hand in hand. Now, companion papers in the August 11 Immunity help explain why. Despite focusing on two different ...

Myocardial ischemia-reperfusion (MIR) injury compromises therapeutic effects of revascularization and leads to functional impairment and exacerbation of structural damage in the heart. Limiting the ...

Common variants in the phosphoinositol phosphatase INPP5D are linked to an increased risk of late-onset Alzheimer’s disease, but no one is quite sure why. Recent work suggests that depleting INPP5D in ...

Duchenne muscular dystrophy (DMD), a muscle degenerative disease affecting young boys, arises from the loss of dystrophin. Current gene therapy approaches aim to restore a shortened form of dystrophin ...