Open Heart

Multimodal artificial intelligence to predict cardiomyopathy development in hereditary transthyretin amyloidosis

Background Hereditary transthyretin amyloidosis (ATTRv) is a rare multisystem disorder with marked phenotypic heterogeneity.
openheart.bmj

Prognostic value of microvascular resistance and its association to fractional flow reserve: a DEFINE-FLOW substudy

Objective This study aimed to evaluate the prognostic value of hyperemic microvascular resistance (HMR) and its relationship with hyperemic stenosis resistance (HSR) index and fractional flow reserve ...
openheart.bmj

Comparative study of coronary artery disease prediction: conventional QRISK3 versus enhanced machine learning models combined with particle swarm optimisation algorithm

Background Coronary artery disease (CAD) is one of the biggest causes of mortality worldwide. Risk stratification for early detection is essential for the primary prevention of CAD. QRISK3 is known to ...
openheart.bmj

Implementation gaps in contemporary heart failure therapy: a two-country nationwide analysis

Background To assess implementation of contemporary guideline-directed medical therapy (GDMT) for heart failure (HF) across two nationwide public healthcare systems, including treatment persistence ...
openheart.bmj

Long-term outcomes and impact of diagnostic coding of patients with heart failure identified in primary care: insights from the OSCAR-HF cohort

Background and aims Misclassification of heart failure (HF) in primary care electronic health records (EHRs) may affect care quality and outcomes. The OSCAR-HF (Optimising Standards of Care of Heart ...
openheart.bmj

Atrial fibrillation in patients with an atrial septal defect in a single centre cohort during a long clinical follow-up: its association with closure and outcome of therapy

Objective Currently, consensus is lacking on the relation between closure of atrial septal defect (ASD) and the incidence of atrial fibrillation (AF), which is a known complication in ASD patients.
openheart.bmj

Impact of atrial fibrillation catheter ablation o’n tricuspid regurgitation severity: a systematic review and meta-analysis

Background Atrial fibrillation (AF) and tricuspid regurgitation (TR) commonly coexist and are associated with adverse clinical outcomes. Whether restoration of sinus rhythm through catheter ablation ...
openheart.bmj

Distribution of lifespan gain from primary prevention intervention

Objective When advising patients about possible initiation of primary prevention treatment, clinicians currently do not have information on expected impact on lifespan, nor how much this increment ...
openheart.bmj

Ivermectin May Prevent and Reverse Immunosenescence By Antagonizing Alpha-fetoprotein and Downmodulating PI3K/Akt/mTOR Hyperactivity

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openheart.bmj

Impella versus IABP in acute myocardial infarction complicated by cardiogenic shock

Objective We investigated the benefit of Impella, a modern percutaneous mechanical support (pMCS) device, versus former standard intra-aortic balloon pump (IABP) in acute myocardial infarction ...
openheart.bmj

Withdrawing guideline-directed medical therapy after left ventricular ejection fraction recovery following atrial fibrillation ablation: a multicentre cohort study

Background Atrial fibrillation (AF)-induced cardiomyopathy (AIC) is characterised by reversible left ventricular (LV) dysfunction after restoration of sinus rhythm (SR). The need for continued ...
openheart.bmj

Predictors of atrial fibrillation post coronary artery bypass graft surgery: new scoring system

Background Atrial fibrillation (AF) following coronary artery bypass graft surgery (CABG) is common and results in significant increases in hospital stay and financial encumbrance. Objective Determine ...