Experiments in amoebae and murine microglial cells show that EsxA initiates repairable vacuole membrane lesions, while PDIM helps those lesions progress toward rupture and cytosolic escape.

New research in Aspergillus oryzae shows that vacuolar proteases govern autophagic body breakdown and nuclear degradation in ...

We're also testing whether LYVAC is helpful or harmful in a genetic model of neurodegeneration, where large lysosomal vacuoles naturally appear. Our goal is to find ways to adjust how lipids move into ...