Lysosomes, long regarded as the cell's waste disposal system, are now recognized as far more than simple degradative ...

A new review argues that lysosomal membrane permeabilization and lysosomal membrane rupture are mechanistically distinct ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed cell ...

Researchers have revealed the structure and function of a previously unknown lysosome transporter. The groups of Christian Löw (CSSB, EMBL Hamburg), Markus Damme (Christian-Albrechts-University Kiel), ...

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications on how the targeted suppression of lysosome function may lead to brain cancer therapy.

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

New findings clarify the genetics of a rare disease called mucolipidosis type II, in which people’s hearts and abdomens swell and their bones grow malformed. A lysosomal storage disorder, ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...

In a recent paper published in Nature Metabolism mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species, Department of Molecular Metabolism postdoctoral fellow Aaron ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...