Nature

Network analysis of gene expression in peripheral blood identifies mTOR and NF-κB pathways involved in antipsychotic-induced extrapyramidal symptoms

To identify the candidate genes for pharmacogenetic studies of antipsychotic (AP)-induced extrapyramidal symptoms (EPS), we propose a systems biology analytical approach, based on protein–protein ...
Nature

Network analysis of gene expression in mice provides new evidence of involvement of the mTOR pathway in antipsychotic-induced extrapyramidal symptoms

Early acute extrapyramidal symptoms (EPS) are serious, debilitating and stigmatizing adverse effects of antipsychotics (AP). Although these side effects usually respond to dose reduction or to ...