An international team refined MemPrep to isolate the endoplasmic reticulum from mammalian cells, establishing that its ...

Human cells contain billions of molecules. To prevent complete chaos, these molecules and the reactions between them are ...

4-Phenylbutyrate (4-PBA), a chemical chaperone known to reduce endoplasmic reticulum (ER) stress—a key contributor to kidney injury and fibrosis—has shown therapeutic potential in various disease ...

Aberrant proteins are extremely harmful to cells. Such proteins can originate from mutations, unbalanced subunit synthesis, damaging conditions (for example, oxidation) and also as a side product of ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

Researchers report that stressed mitochondria form protein aggregates called SIMPAs that signal through GRP75 at mitochondria ...

Textbook drawings of the cell’s largest organelle might need to be updated based on new images. Super-resolution shots of the endoplasmic reticulum reveal tightly packed tubes where previous pictures ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...