An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...
An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged ...
Autophagy is an intracellular degradation mechanism in eukaryotes. The autophagosome, which encloses damaged or excess cellular material for degradation, is constructed from lipids supplied by the ...
Autophagy is a mechanism for the degradation of cellular components in eukaryotes and plays a critical role in plant responses to abiotic stress. As a core member of the autophagy process, ATG8’s role ...
Ischemia/reperfusion (IR)-induced acute kidney injury (AKI) occurs in a range of clinical settings and is characterized by pronounced inflammation, but the underlying regulatory mechanisms remain ...
A 2026 collection of five reviews and one small tissue-expression study shows that autophagy can restrain or support solid tumors depending on tumor biology, disease stage and treatment context.
Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of its most ...
Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...
In Japan, cancer has been the leading cause of death since 1981. At present, surgery, chemotherapy, and radiotherapy are the main treatment options. However, these treatments considerably reduce ...
Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the precise mechanisms by which autophagy maintains brain health have remained ...
Noboru Mizushima is a cell biologist who has studied the molecular mechanisms and in vivo roles of autophagy, a process by which cells degrade their own cytoplasmic components. He is currently a ...
Upon autophagy induction, ZDHHC13 is recruited to autophagosome formation sites together with ATG9A. ULK1 is palmitoylated at Cys 927 and Cys 1003 residues by ZDHHC13, and the ULK1 complex are ...
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